Jude Law - Alfie
Renée Taylor - Lu Schnitman
Jane Krakowski - Dorie
Jeff Harding - Phil
Marisa Tomei - Julie
Kevin Rahm - Terry
Max Morris - Max
Omar Epps - Marlon
Nia Long - Lonette
Gedde Watanabe - Wing
Jo Yang - Mrs. Wing
Tara Summers - Carol
Sam Vincenti - Felix
Katherine La Nasa - Uta (as Katherine LaNasa)
Claudette Mink - Bitter Girl
Anouska De Georgiou - Tonya
Anastasia Griffith - Chyna
Jefferson Mays - Dr. Miranda Kulp
Deborah Lynn-Shyer - Pretty Teacher
Veronica Clifford - Waiting Room Nurse
Sondra James - Mrs. Liberman
Dick Latessa - Joe
Susan Sarandon - Liz
Graydon Carter - Wes
Steve Morphew - Waldorf Doorman (as Steven Morphew)
Sienna Miller - Nikki
Finlay Robertson - Bright Young Thing
Edward Hogg - Bright Young Thing
Martha Cope - Bright Young Thing
Ben Jackson - Bright Young Thing
Charlotte Moore - New Year's Eve Singer
Cosima Shaw - New Year's Eve Stunner
Marjan Neshat - Traffic Cop
Gilbert S. Williams - Elvis, the Doorman (as Gil Williams)
Saidah Arrika Ekulona - Gilda, the Receptionist
Stephen Gaghan - Adam
Paul Brooke - Flower Shop Proprietor
rest of cast listed alphabetically:
David Monteath - (voice)
Amber Cather - Girl (uncredited)
John Gomez - New York Businessman (uncredited)
Cynthia Granville - Hooker (uncredited)
Steve Hamm - Janitor (uncredited)
Daniel Solazzo - Pallbearer (uncredited)
Gunna Wilson - Flight Attendant (uncredited)
Dianne Zaremba - (uncredited)