Glenn Close - Cruella De Vil
Jeff Daniels - Roger
Joely Richardson - Anita
Joan Plowright - Nanny
Hugh Laurie - Jasper
Mark Williams - Horace
John Shrapnel - Skinner
Tim McInnerny - Alonzo
Hugh Fraser - Frederick
Zohren Weiss - Herbert
Mark Haddigan - Alan
Michael Percival - Police Inspector
Neville Phillips - Minister
John Evans - Pensioner with Bulldog
Hilda Braid - Woman On Park Bench #1
Margery Mason - Woman On Park Bench #2
John Benfield - Doorman
Andrew Readman - Police Officer #1
John Peters - Police Officer #2
Bill Stewart - Arresting Officer
Gerald Paris - Doctor
Joe Lacey - Veterinarian
Brian Capron - Television News Reporter
Frank Welker - Special Vocal Effects (voice)
Arthur Mullard - (voice) (uncredited)
